	   SnapGene      ògacggatcgggagatctcccgatcccctatggtgcactctcagtacaatctgctctgatgccgcatagttaagccagtatctgctccctgcttgtgtgttggaggtcgctgagtagtgcgcgagcaaaatttaagctacaacaaggcaaggcttgaccgacaattgcatgaagaatctgcttagggttaggcgttttgcgctgcttcgcgatgtacgggccagatatacgcgttgacattgattattgactagttattaatagtaatcaattacggggtcattagttcatagcccatatatggagttccgcgttacataacttacggtaaatggcccgcctggctgaccgcccaacgacccccgcccattgacgtcaataatgacgtatgttcccatagtaacgccaatagggactttccattgacgtcaatgggtggagtatttacggtaaactgcccacttggcagtacatcaagtgtatcatatgccaagtacgccccctattgacgtcaatgacggtaaatggcccgcctggcattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtctatataagcagagctctctggctaactagagaacccactgcttactggcttatcgaaattaatacgactcactatagggagacccaagctggctagcgtttaaacttaagccaccatggactacaaagaccatgacggtgattataaagatcatgacatcgactacaaggatgacgatgacaagcttggtaccgagctcggatccatgaggcgcgcggcgctctggctctggctgtgcgcgctggcgctgagcctgcagccggccctgccgcaaattgtggctactaatttgccccctgaagatcaagatggctctggggatgactctgacaacttctccggctcaggtgcaggtgctttgcaagatatcaccttgtcacagcagaccccctccacttggaaggacacgcagctcctgacggctattcccacgtctccagaacccaccggcctggaggctacagctgcctccacctccaccctgccggctggagaggggcccaaggagggagaggctgtagtcctgccagaagtggagcctggcctcaccgcccgggagcaggaggccaccccccgacccagggagaccacacagctcccgaccactcatcaggcctcaacgaccacagccaccacggcccaggagcccgccacctcccacccccacagggacatgcagcctggccaccatgagacctcaacccctgcaggacccagccaagctgaccttcacactccccacacagaggatggaggtccttctgccaccgagagggctgctgaggatggagcctccagtcagctcccagcagcagagggctctggggagcaggacttcacctttgaaacctcgggggagaatacggctgtagtggccgtggagcctgaccgccggaaccagtccccagtggatcagggggccacgggggcctcacagggcctcctggacaggaaagaggtgctgggaggggtcattgccggaggcctcgtggggctcatctttgctgtgtgcctggtgggtttcatgctgtaccgcatgaagaagaaggacgaaggcagctactccttggaggagccgaaacaagccaacggcggggcctaccagaagcccaccaaacaggaggaattctatgcctgactcgagtctagagggcccgtttaaacccgctgatcagcctcgactgtgccttctagttgccagccatctgttgtttgcccctcccccgtgccttccttgaccctggaaggtgccactcccactgtcctttcctaataaaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggggggtggggtggggcaggacagcaagggggaggattgggaagacaatagcaggcatgctggggatgcggtgggctctatggcttctgaggcggaaagaaccagctggggctctagggggtatccccacgcgccctgtagcggcgcattaagcgcggcgggtgtggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcccgctcctttcgctttcttcccttcctttctcgccacgttcgccggctttccccgtcaagctctaaatcgggggctccctttagggttccgatttagtgctttacggcacctcgaccccaaaaaacttgattagggtgatggttcacgtagtgggccatcgccctgatagacggtttttcgccctttgacgttggagtccacgttctttaatagtggactcttgttccaaactggaacaacactcaaccctatctcggtctattcttttgatttataagggattttgccgatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaacgcgaattaattctgtggaatgtgtgtcagttagggtgtggaaagtccccaggctccccagcaggcagaagtatgcaaagcatgcatctcaattagtcagcaaccaggtgtggaaagtccccaggctccccagcaggcagaagtatgcaaagcatgcatctcaattagtcagcaaccatagtcccgcccctaactccgcccatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctctgcctctgagctattccagaagtagtgaggaggcttttttggaggcctaggcttttgcaaaaagctcccgggagcttgtatatccattttcggatctgatcaagagacaggatgaggatcgtttcgcatgattgaacaagatggattgcacgcaggttctccggccgcttgggtggagaggctattcggctatgactgggcacaacagacaatcggctgctctgatgccgccgtgttccggctgtcagcgcaggggcgcccggttctttttgtcaagaccgacctgtccggtgccctgaatgaactgcaggacgaggcagcgcggctatcgtggctggccacgacgggcgttccttgcgcagctgtgctcgacgttgtcactgaagcgggaagggactggctgctattgggcgaagtgccggggcaggatctcctgtcatctcaccttgctcctgccgagaaagtatccatcatggctgatgcaatgcggcggctgcatacgcttgatccggctacctgcccattcgaccaccaagcgaaacatcgcatcgagcgagcacgtactcggatggaagccggtcttgtcgatcaggatgatctggacgaagagcatcaggggctcgcgccagccgaactgttcgccaggctcaaggcgcgcatgcccgacggcgaggatctcgtcgtgacccatggcgatgcctgcttgccgaatatcatggtggaaaatggccgcttttctggattcatcgactgtggccggctgggtgtggcggaccgctatcaggacatagcgttggctacccgtgatattgctgaagagcttggcggcgaatgggctgaccgcttcctcgtgctttacggtatcgccgctcccgattcgcagcgcatcgccttctatcgccttcttgacgagttcttctgagcgggactctggggttcgaaatgaccgaccaagcgacgcccaacctgccatcacgagatttcgattccaccgccgccttctatgaaaggttgggcttcggaatcgttttccgggacgccggctggatgatcctccagcgcggggatctcatgctggagttcttcgcccaccccaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctgtataccgtcgacctctagctagagcttggcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaagaacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtc  7å   &   #         #                         $      4   #   $            "                                    !                                                         $   *            /      !   1   !   %   #   (      !      &                              "   !                     /                                                                        !                              
                              "      )            '                        )      	                                       
                                    '                 !                           "                                 "                  	               %   +   &         ,                                       )   #      $                     !         &      +            .   (         )   &               ,      .        & š_Zwx¶·¿ÀêhNOPUZij‹¹ÂÃg	h	‘9ü9»ÙFÈyµÇ#  š1›½Ùo`Mh¿[yæktŒ8
Ú1ž¼GÉÆžnxE · °ëQVÄíu	§	”
?�:Úz�È Ø �(S¸ÁËi¡[–ºi	º	Z’î-:ýÖŠ\rÎ¶M# 	 d -´¾pè9NTi¥6\z’çöOR‚lã	±½ÛCÉHo ± Ù…ý$u«
ƒ
š
â
Ïe‘ÃÔùÇüŠÊ§.FV   ‡œËêa2°o�9
ð#?Ëä5xª½Ê¬…YŸºyÆ  ›2Ú˜µÀèbÔ:`ù	Êí˜¤2Ÿa  ±e«}ƒà>RW“îó¨	•
Ý
@¶b�ÛPöŸµS/  E¿ÞÅðš¯é?Y~”Û)f ¸ mŽöv	®	Î	Q
/š;†ô9P·/{°ïŽÉ g ì"
Ö……ü{¦ß½$ ½ ‚ôûe¨Üê“ï.} 0H•ÌÏzM]“¬SrÏœ‹Wm·N � Ï@sÊA\ƒ‹	²
ú
[Ð;q!Kõ24 • U6Q}	:YwÇë	$)Tƒ—Ÿ»N	j	¦
î
i´ÆHPk„Øá#o€“þ‹°×‹¦� Ãs¨k# Ù L(ã@W‡ŸÍŒ¹ÂÌùj¢»	I
†ŒÀ7ål‡;éô¸ÏÚ$ e òé"U&0QÞè÷PƒŸ"m¦„Š¯²¾FÎ3KN’p 
 ?q jÖ${üD^eI¬˜HÖ n .µ¿˜9ä	#ÊåN¨øŽ2^ y -ä:O¦7]“S\
œÜ»¿ôÆ-t¾é–á1ŽÓ#œ" © M²4147>sþv¶
þ
§1ÐñÃÄ€È°ÍìbÛËÚÐ/€ YoÚX%¬›
ã
`®f@‚šÕVýQ�¨ºW·Ý ¬ }†v
„
¾YÒ’6ÂJG_¬ AÚ¡°
ÂÙúÐ‹� 8 Ñ hÌÒVb3Ž«	 tsÌåK«â Þ ˆ�Ç	ºËk­`i�z¡ ð �®p|	¢	/
:
C
a
$yÿgm†F ®¯    ·ëP±´ñö	@Žßè6®¾Zem»Ç0…—ÅÇØü   r~§ú´þ¨ÏÄ;Ë	Ý	Ëëî- Q .A€ë ž ê ½Õk¶ÁÕayþd¥]^Q ÷ œ3“Ûd™Ãec“¾ú	mV�3wbcP+ š Yd)s¢£bl{�Øé÷™÷	“	©­£A™ÛEIhœ-šZ! ²…87Š�®ÿSX”ñô¸	÷	�
˜
à
Aßc…“7QÍ³¶ˆÝQ f¬	©	­?¸˜çß)0! ] _ Ü?ïˆ
Š
–
Þ
}‘–Î÷[TáO  s ~„áÂì‚	·4çÜ%‹ †¤›ðâ p (‡;×µ	ªæù™	*] FŽÀë}Ð°ÿ@ZúÓå L �·ÞNÆ¹
âdñN^W›ê•ÕÜðgQ° * Ô Óì#Dwß(Å4 a ç ÌÚà	
­‡4þI9<¡É×`Ó\ C ¹ ü 7÷R
�
õ ¸ó™'�±ãð� À n�ÁÅ„§ÝÏ	—á:�Qu08Þ.b 0…G	w	¯	ì	
R0›ò%<Ì‰—ò $ª>|®ÞÊ h èÜ<e"†ýX_ uªýT·š@íAX	Œ
Ò
ˆ¤H†J§VÌ@p ¦ Óš5#
×ZI|5ü• +§æ	Ÿ
ç
'²>´Pà¾ kŒ	ùf‘©ÚèëÖ{~–Í/¹DN‘˜­�-®Už w Ï t
/¬½1IÐO”T�.–ŒX¸O ¾ å 5ƒ‚	ð«{üU
sËn$ u Å õ÷üÐÝæü		Œ”Ôù!#·B^�Ð4âLÕ2ƒÏ* ÐAt*"€ »QÆåKN_B]€þ¯
³
÷
û
�,ŽÇÑû<èÑru‹@CN×Þö� { ‘ 1‹e½
Ö
Ívãî<‹¸å4¦%3= > ¥ -+0„ßÂ
Æ

„¶ö%	,Ç.3Lþƒ ! ËŒ	(\Á"ùòÑ/ k Ç Vz
ò
%ô*-„ã%±ˆ¶^
jl…âþ$p�ŒÀØ§ÆŒ+|Žã1é&ˆÐ † Z7~;ÈìE		žIQÙ'”�±pë¢ÄE! Y – ² Ê JRÚ† -	O	„	µÇÞ;ŠRpÈßéŒëvh¥Òtl!1 3 R /æþZx¾uDU˜¼$	]	k	§
ï
ÔoUÿù§`p�¡!Dƒ�Ýäƒ¡©[vµc�! ; %.��óUK	@
‡�8wz6[Ó	Vmˆöv£À¢ÇÐ
Û:% H Ú “ç�0X—¬Îïº_ÏÓ	B	¼	æ]'<êõkxïÃ#?…ä# Qäõ<AˆÉ9•ÃÍúk�¹ÄîJ
�–ÁNyÕÞ¸6¹Lñ( #M]kÇðö)FI ¨v£áÒ	 	Â	Ö	,8AMWb–¹›)TÓ
&)€i ¶ ™ng¾'RµÊé hÁt	¦	7
“
�ûÇ�qÍDLŒÆ! Ê´S¤ç1aØ9Q�„#_n°É>ã4£Óø`„X¹Å- f |‚ß =Ü
.…Oèû“& � ” ¼ óê#V†ø@‚§¥
±
í
ù
…‹³¿ÅGÏL«èóq› JŠ1 ,>!%PÝžƒûEóÅsJM�§ « @Ù3|36r¯µ
ý
¦_ÁØÌÏPaÙÏI�¶  Ý ¶OUŽfjEd­Æ_®× r¡¢k×xÊ	ýc¨]™ r Û6‰­�	·	ö	¬3Íæ²‡…ÜàNšá ) K o �¶Òë"Cv:¸
 ©cÔïùÒ3 B û /ÀË�
Q$Ë3ñ©òÝ
H&-�Ö_Ý S¥*?¦™å	ž
Ñ
æ
&IOû? ‹�Ùå 			‹Ó«¼ª.N¶—Ê�,-Ô­�" z )ŸPJM^d®
Á
Õ
ö
	Àõ Æâí2tŠ?B·øŒ$‚! … .yÙå½ñtóCDµ\	]
�ÓÝýÇêou‹ê* ‚Ü
u´ G "�$;–§Èî8”T^u¸ÒÒ¿Ô(wîÂÆ Ž “ É³8?ÿg6
„ªçòWœ¸Ì‰Ä0CK ª  µNT�Ü25w®ú§òÄ×i\Î`c Úê¤5�
·
å
ÿ
¨2bÌH±ÜîÛÑÕ>™à F „ (xŽØò]tä[	À
ÒªÑMÿÅÓ�É	í>¬� Ÿ´Û­œ
¿
ä
ÑaƒþËÒ©Öæñh V·í«˜Bß/ } Ðã™	š	›	U
V
W
i
j
ÏÐgåð:;þÿRSTU�µ¶ÕÖ¨©ª—©»'(5?@A¸¹Þ ~ H	ÑäZ3&b	X
k
hAú›<Ð×ã6XºÂ ÂˆpY}«œ	
¯BW‘ü½ª¼)¾ I{­ 
~ºåY
…
¿xiÓBñKâ3Ø�7Y­ x–_~|ó	Zû²º*Ks}H`w»Ã  ¡ [4A‡'l
w
{
Í
qœ­øÑ . ­ Òc	g“7Ã=äè a�Ö�bq
?ÎŒ6‚« ‹ íZ~

f
`°·Ú�Ñ*¿ >Ãð:‰n�	
2GÃÜCîB½’ýcç‘½ø BÛÞq¢¬±
Ø
 XûXT¾:ç  +J®/c»–W4�¬	g!mÍF`jÔòƒiíó § |'¦»ÍÓðcÔ/ Z
TÀæC€¬ã4ªÙöŽ•š Ò ƒæ†
LXÝ—ŸãZ® 9 åiÄ#�†�»
Ä
uty'LÄS8 @  ‹—‰l}È	ô	$¨‰ÚF+LŠÄ <y&²4
ïüÉÌfa» {I¼ ß ')ã$�ä[»òôx¦ á `†`º³l®j‘t~ag¢ ¢ í ô o¤÷±û5ð(2qN
%*½å�ùYB¤}’ ñ ÿ P]\¯á£	x
Î
õ0‡G¯Ò z € ¹žB}	0
;
D
b
m
r{êh ×¡9°…¨²Õ ËˆDI'
|
[¡LŸz n.®qC  WVÀ-d	¿	
hÜ³¸~ó”8>FhNÆ! 	×à{Ó¸Q’ƒ²µ÷jàø] `	HU€�Ä5²å´†æ¡‰  / N ® HÖ
È
òAKé7¿PìÞ[n¼é(1{Èý  ìÈ<æf�¯£»;fÈBí÷˜Ù  Ö C½˜×©Å��½c‰	Ì	ì.îµÁwlvT bbÐŽ<Ìéï!c¼/a�gƒ s¨ûLµÑE	³	Þ	ê	Ã—7¬ì ã ‘îÿ¹Îúr
*ˆR¡@ÏBáJ�ŸY �ïr”¼	ÈÖbÿa¿^‚¥ÒH+ , ‰ Œ Ÿ î�ÇÖl[z
g
^eø«µ8À ë :Õ%Fy¾Â±¦¸óÛ“ˆ¤Ó
 ·pþ	
³_ÇR ÄGN¿
WÄ ‚)tn{û,ù ø ;išÄ>ncC¾Éd ?�Ë4<ÜŠo­d	ž	Ýdþè’ # ”ñef H”û	
3HÇ4Dïx¥“Qé6¾ìci › ZáàF!š*	ªšÜFsbü©.#“¥[€Í `Í“£m|‘šÑ£oz²Ù
!¤§Jn x¿; *•û¯ÙøirŽ	®P—Yi°öÂ$ç e¬Ct¤Ü[c¶ßê­ø”	
B´×Y�U›èô ¯0€¼^Yå MTYsŠ•¸¹	>Y,ŽÕ8‰Ø[" c ,³†—°ç85‘¯ÓNüâ	ø	

‚
™
á
¼"BÎìdw©È~‰¦  dÝòõ­	P
aó8„}´Ú(¥ÞReî.) KTÎ?rÉ5P|9X?Ì‹žhàä"nGk†”¯ËyRÎp·~jÙô m ñÕ/!8¥[
›®,äèàM«÷1GÕ"› ¨ Ln0½ÁÂ�™5¯ëÚ^« 7 ï g­³¡	ª	Æ	.
`
õsr�ç¹­l�–û' ™ é ö Xq}¦ù(’³ý§¼ÎÔdjÃö˜’ö	Ü	lU@ÚDv-O*ê \ ^ 7Áð€
‡
‰
—
ß
 „’6•—Þ£( Ó Ý'†'ÖáM]Ïåø˜\Pä¯ ` „ÄÙÜ 
~àŽŸ–7; âÒ[ ç™4@‹
‡£±GÛ=Y!³4UË” t Ä j�øzû T~�Œ3á1T   ¤ !ŠÅä*¼
Å
€Ì'Æuƒç+-;Šä¥ýñ 2 Q X ± É I…,â$‡ƒ	n&TQ¿èÅ¡è‡D bœ) : Ææ-Eô/òŽÃÎàí	?
•v¸5Zš(MU\Ý	&¡K	>h9ã µ » ˜m<Às	¥	’
ÄçúšÅ	 =�É	rËÅ^µ A q ú ŒR)ˆÊ€	¶	õ	Ð
%«2G,M !Š€~Ø	©nŠÛ‰
+³‹ E ƒ '�ã5
[›ÔJ GÁ‡³ªa	T
ýÊÑ gÏÔâìû¼–½ z^@ò	z
pð~á÷2±)| =�ì9e
p
1FíÍA€¼bæ  *‚ä.Œœº
~S–õhòR à (#%k±3
ãî_eñó ó þ ¸öO\ÊH&
M
z K)¼äXÖ8ÿy|‘§± M ßU‘Ç
åÛe\ŸòOT¢œºë:EgÝ±'³ìåˆ Õ â B¼íKa€ùˆ	‡í»´ÀIvfku + ˆ 9Ô$ExœÆî	÷¤ÆG’£
 ;M=GÆ
5bh _à)n–³am¨¯õw’Ì b Í>qÈÜ¯Mrá	O
»=+®ÊˆxZÙ¤ dØ¥ ˜ è î õ p¥ø‘²ümõ 	Û	-
ŒL®kÔ]~ª [ Ã6˜Û3ÿ	à¢Úß5<ž6:¢Ê“ £ Ã D‰ñÍß)	>
Ë&÷ST¾æúÿS:J0=Cag ´ º Qr		¤	‘
Ï
ˆ²´ D ‚  ]†Œ©âñ	S
d
o
y
ö1šÎÓá(• ò ý -T°2
y}ãíS¡¹9f°²ëäñ{‡� 8A»^Lø‡	ìö§ôHv‘	Ë Â p�ÂÇCˆlÞÚ	,
=
ºÊ¡;RØ59j£/c© � º…¨q	~	†	ð	1
c
n
x|ëâÍà±ê”
†³' Á oÆÐ	Ñ	+
<
stuvw·¸¹ÉëŸ r˜!"#$1234q¢Ìß#	qr  Ÿ6ŸÞ)	/	<	Q	Ò	E
ìsi™%�v»Ôr:$sÖ Ì *	H	Ó	F
íM =jŽÐŠÃóù; º²ß ûf °	{&%¿?nr t  q‰ÇEJ¢0	=	í	(
}
\1œt&)|Í/¼Õ«s%D¯! 1† 7 ßÌñ3	8	R	x	
S¢€óáoš‘¯djw˜}mË×  èue	 
G
îNiÉ�9ƒ‹Äôú»³ WÁ–¼‘	¡¹Ý>kf?à éýÝ:=å•#‡‰þG<YO]`Çî i Í X.+	@	I	À	Ô	´ôÑnzi! ' z„A³¶�
Ó
‰áù¡žÅKï&…+µsÍŠ 
v«Øþ|¸ÔR‹ÜY	
Ë
ø¥I§F^³æ‡8qÂu áU¹�î!BIk^|ÂFV�‡Ø¨@oëAŸ¢e˜ –g“›DügÆ±	Na
'©ñr£6ß•À£Wç" 0 5 O ¯ 3 \hW×6K£~
“™óqêu*6[ßæ}2|&E I!Š›ÈFš¾_	$
}0ltê6ý 	1	î	ý	)
�Ø'ÎQbJ¬o½e°Éþk  % §1rÔ>	
É
]2BL8À‘½Öí\)À– 2óty	5JT_4�³�›¤e#™µ<îxÂÌ ¡¡©àíªÖøþ<ç	
£çgp³?°¼QC«ôøÚ 8À,ÐJò&	9	ôDWâ°’k“gÉá·¿n   T ‡Íw²F¨æ	É4	S	m	 
©
è
ñ
(=Öûx…¿S~™Ø  × ™ØLv¾gìf	Ùí80�ºEÅxmw´  éŸõªïÊ—�Â«ûÉUŸ D¾l�
ª’Í	!
™µÕïO„™®¶õ>Xž.z¯¼" ú'vÆâž‚dÛéM	Š	H
6Ojƒ×|’/ŠÎ¥:Œ’Â§Vl x ã#—‰Í]º¾2"d½•0‘—Ò�] X=Wu
0­ðXÑ?UŽ¹Ü  Ð Ñ{	B
ÞJþl/h„Äá � ccÂaz�½’	¬ê¢,€HPg@\›,bYP „�þë	|Þ>·æ$ŠÌZPï	 €Mê´	Ä|Vþ ¿ æ 6ƒ¦F	ß	ë	ñ	¬–ýˆtÿ#˜=8aÈ­ t©ü¶ÒW	;dHW^oí v Î ä 4öøÏçûs
Õ"¸AC	K•‚Î =  0º,/Þý+�úµ$ÐMÖ3Ý<Ð% j Æ Yý°	#	,	:‰oœÞø¦_go{€CŽ¤Ñâ0ã%‚ ZÏ+ P\j’ïõH«œÑ		A	J	Á	Õ	+7@LVa�y•õSux¢Ò%·5jð"„& {�Rf…£½æ`´É×€^�¤
°
Û
ì
ø
 -�È=âú¢ÆÒ÷_pƒI,‹ Ü +¡Ø2
Oq´
ü
‚¥bÀLŒ¦DO­ØÎŽ ( J Ñ!Bu>¥¬Ž
PðÓñ†	„ú%ßÜ, #ž¼ðs•ÇíBILC·Ñc´ÿ	­
Ô
õ
ŠÒüµé)Ÿì'svA,¶ÁÅt÷ � ’ Ùé£wÈ×SŒñ\fZ	ù¦©LG=_ˆ=Ã | Ïâž2|˜	
h
¾
ÎùA¨äï9´§&4>Á -   w•¬ÿ}¹{Ì
fwJ¬çŒ¹rv Š `ÕïmŒÝa

×
_WÛ¶>Sæ5�9÷ ¦ &b•¥ºïÃÓ".…Ã
fl&E_ÃW‚Ü©”žì™ ? &;Šâ#…§ˆ¹ÈÙEÿ‰f¥ ì n£°úï1CàZéž-ô/ApB£„Ô ÖGVz¿‚Õ,¾	Ç
;Ji²·÷}
_G4AzöM  —¸Ðœ¼ÍD	²	é	)èÂbà`–žXS œoq“»ýÇ]ª²´ò¾7‡Ò " ÊFh¬~ÿ	
(s¤mzÈèúë «Ì’”ßú EZ™®µÐ hy�	O¦rÖ"Á#¤óæ) S4O{]æ>ËXÒäûL‰·	
Xã!ëv�7¨Ç×}o|'}-# 6 l WKiÂõ.—‘²7¤Å	_
kšôr¼qÁÙ+u,ê~NFúé &…&ÀØÕ
†°ÿFƒ\�” •²ä3'Ñ$ 1 P W ° È ÅH ,ó.ã+”mÅ%Y‚™P[*,}� 2àç‰ãü ù <œÉ¿	Ã1mqÊÄ 8?`	0Eoàì»ë  õ["jÉ‹G›
%
L
ŸJRÚ(ž~dD&7þ ‡ :J›Å<íFm
	•²£¿ÅueF Z — Ì=Û—®Lô	Ÿ	þ	ß<öR‹ÙSÉÞwK­ÿf ³ @,KS‹ìR¦8euÊ! ž5Ý‡k
(	.	;	P	p	…	Ù	ï	*
¶ÈžqêºÓipËé"“p Ë púeÆð¡2	7	à({�ÏciÂø¾m¹±ÿl çtü•»?	�	
È 9ämy‚ˆ\í& & •fyC€ŠÛÅ
Ê
MÁE¨ðq¢¦E×Þî]„”*¢ê7žÁd— $ 4 02ÿ[gV™½^	ü	’˜p5ka�åd¿j+  S ¨òs©¿Õ÷ýv±;EÏIå%	l	¨
ð
4I^Õ3CVú²"„’¾Rªów¶Á &uáKžôL	Ø5‚˜´7‘Ô‰œ¤Áª=W¦Èyk  œ â`y"Vz	A
ˆ«\
+WýG[š+ÑÃ\Û Ž¥êV	{¶cý"V. < 3O[iô/Gª›+¯	"	*6?KU`Ž9xn›Ý÷tw¥f$£¶/$”ïÜ�Î;Í( I Û  ×1e¢ì=H¤«pÐ³	£
¬
Ú
ë
ô
O¤´(ëöoðƒ¬ÀÄù$Û _”è¢Îávð`{—	
¨KVÚ@=R€<ö %m‰¢a¯ù”¤îÒÔ½	":Yeèh�D^Dyõ@�) ÉªE‘«ÏÞùÿYn}’˜›­´ºÏ»xÌC	è	ç¥qÕ±½ly!�†êå& V R+JÁå-=Êâ–Ñ�úÔÄ	¯»EX˜OZ“Ö+|”Ÿ±Mâè  ô9l	
K
/DÂßºÃ% +–ùjKÅïó'	6	:	o	Ø	õQz¹Á7÷hÊ¸o ¨öüB‰°Ú:sÄÎûºä�	‘—ã±jl‡òÀ  NhJ_x©¤®é!	U	)>×—*µüZ!*VUjÚ, $^lˆÈ®øDuÎÝd¡³¹ëGªw
Ë–	¢
«
ê
ó
9NXdœCUÔÙ‚œœéõ  U ó*I§áãùÓ	5	n	Ã	×	
.Cº*{†žÀ.  fgñò­÷GH¥¦\]^·¸à©âçèÊT	•	¡
ª
é
ò
-BcØ'()yz T�š›Ù  -æ  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                          +                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   	                                                                                                                                                                                                                                        (                                                                                                                                                                    	                  
                              .      
            	                           	         	                        	                                       .         !   $         #         ’   P               $      U                                                                                                                                                                     +                                                                                                                                                                                                                                                                                                 	                                                                                      (                                                          	      
          .  
    	         	   	        	             .   ! $   #   ’ P     $  U   n‰  o«  oÍ  p  tY  x¯  ~ßÝ	©A²	$¨K_`·`Ó
`{›´=ëý£ºPð³
û
ã	J ¼vv
¨#Yè-MÇ—ºÇç“Š-lÈöã	H½
¾ MÇçkƒõ
%ì—„ºˆ Ýß		$	B	½
8‡�…Ùð{�öITÕU˜
CÇÞ}òÑk{3@Pšä{9@^P{@P@ä@ñb¥EMìS¢£
ë
ö9‹ä	Ö¹Çö·ÊŸ ·Pößè Ê„§”âí€-² x-`ñÃ—Ù
çÀÊh åñèîóÂMb»üdÐ›Ðç°2
í†ø¿r§ú´ë^eîø1—Y€,Þ3ÊÞ‹	“¶Û!"	÷¥-–œ6«Ì‹6äk†:Ù~ †k
KÁêÿr§ú´“Q më‹ã Ûø Ð -ä¿›ð ðJt•×¡ÿ \x
õ0 Â=~ ¡Z·ðÌäê-ä¦S¡–ºi	ýbüäˆí“v„Â

%Æd¬ ³õWªN‚j í&ã…ÕÅä£Fû		“]Ï ÊÞê9¥è6’ ·ÀRh¡j	v	‹	¦
î
“¶Ûù !¨{ÉæÇÕ;²ªKE]ÁÄqjÖ˜K²	Âa”Jde›¡sŽ»Kù¢
ê
eˆÂ×7DÖ{,³©<xv‹ïA%àK	Óˆ£¥õ!P¯6ëG«
ó
ãˆ¶Œ~6„,ÄYÒa”eDÍ  -ä¦S¡–ºi	Z·¿ý›ð¹¨˜Û^a”KeÂDajñÃw Mz~õ%¨Ï€„	 	K	¯
Â
÷

(â½ÿ!%NRˆ£
'”ê<Ãa”›Ž»eDÂ„Â

%ÛK êð?5½YdºÆÆ×Ï IV,¾	²
ÞF(úJ×…¨Íà”¨•ó5JT_#µî-ä�KæÁÇêÕ;²ªÿžIL­
õ
sA+ç†Ä
âç eîØ ç À¯	æ	÷	^eúðî  Í ¹RÀÖw›£ø¥áê=u¡ûaÄJ¬^¨«˜  ã ™Qa à	%K	ˆ£ð¯´ü)/$Î‡[Ð• ãÅð´ü)eî‹•EK]ÁwÝš ©EZó 
ƒ»¯>Ž) Ò"Cv35|9õP
¯óî› ê°ð?5½YºÆ ëŽ®eÇ—ØRå=e¢ÊÑú£
Ú
ë
Ööo|¦Ó•qjÖü˜Ç "»òÆ*KBþlÑû$�è+|Ž1ru@ˆöØ L(Ÿè¸ÁËi¡¢º	˜Îß½JK×Ø—7œVje«¨	/ “DgNÀ£è˜ß½"»ÆKBþÑûèru@öÇ ò*l$�+|Ž1ˆÔ½	:h^yõV3«	 ÌÅ��c‰	.Á�z; Ç ù".»òÆ*KBÚèþ�8lwÑÖû${~�mÍövè+|Ž‘¢1ru@ˆÛöU:Rå=JKe¢ÊÑú£
Ú
ë
×Ø—7œÖöo|Vj+Æ
¶ö	3L8 hŽtsKN
W n{,I  =¤«Oðƒù$ÛËa2�Ëäª;Aö& yî„*l .7¤š+Fš1Ù¿1ž§Ÿ
ç
'C½©¿Ì	‚îbµüÒ& l ³ y.7¤š+î„*F¬†„ßF(smzúþQ A€nNh©®!	)>fë/¹D¬ “de“˜ä	ú	yÿ3m’6wÂNPê,;Pd@W^íð5 èh6£y	™îóqÉ*�K™ú}ÂÍEùÅï6	zÁ÷¸²7>þË/7Žëš÷	?õ@óV�)å© M14vñÃÍb1	'Îb½°þk˜ä	N“de“ú	3wPš	?V)¬ yÿm’6Â; ù.Úè�8wÖ{~mÍöv‘¢ÛU:F¬(smz†„ßú§ /À€4Ù {?n Tv Î ä 4öøÏçûs
Õ"¸AC	K•‚Î< 3O[iô/Gª›+¯	"	*6?KU`Ž9xn›Ý÷tw¥f$£¶/$”ïÜ�Î;ÍkŒ	ùf‘©ÚèëÖ{~–Í/¹DN‘˜­�-®Už* Ô Óì#Dwß(Å4… .yÙå½ñtóCDµ\	]
�ÓÝýÇêou‹ê* ‚Ü
u´u Å õ÷üÐÝæü		Œ”Ôù!#·B^�Ð4âLÕ2ƒÏù <œÉ¿	Ã1mqÊÄ   ·ëP±´ñö	@Žßè6®¾Zem»Ç0…—ÅÇØüÙ L(ã@W‡ŸÍŒ¹ÂÌùj¢»	I
†ŒÀ7ål‡;éô¸ÏÚ&uáKžôL	Ø5‚˜´7‘Ô‰œ¤Áª=W¦Èyk¦ &b•¥ºïÃÓ".…Ã
fl&E_ÃW‚Ü©”žì™G … • Ù "LU.6Qy}�Ùå	$(:Yw½Çãëñ	$;@Wt‡–Ÿ§ÈÍîó)8CTƒŒ”¹ÂÌùDT^ju¢¸Ò—Ÿµ»N	\	j	»	I
]
¦
î
i†Œ�´ÀÆÓÝ7HPk„Øáåý#o€“Òþl‡‹°Ç×‹¦êou‹¿Ôê*;� éô ‚Ü
(w¸Ãîs¨ÂÆÏku´Ú ? ¦ à &(*;‚Šâä&.b#%k•¥±ºïÃÓ".Œ…œ3
º
Ã
#f~ãSl…&E_§ÃîW_‚ˆ¹ÈÜeÙ–©ñóõEh”žìòÿR‰f™¥s¨ûLµÑE	³	Þ	ê	Ã—7¬ì  ¤ !ŠÅä*¼
Å
€Ì'Æuƒç+-;Šä¥ýñ ¡ [4A‡'l
w
{
Í
qœ­øÑ¨öüB‰°Ú:sÄÎûºä�	‘—ã±jl‡òÀe òé"U&0QÞè÷PƒŸ"m¦„Š¯²¾FÎ3KN’pD ‚  ]†Œ©âñ	S
d
o
y
ö1šÎÓá(•f … s¨û*Lµ.yÙå|‚•½Ññût¯ÙóøCirßD =µE	\	Ž	³	Þ	ê	]
Ü
�ÓÝ.®ýP—ÃÇY…êiou‹ê* O‚°Üèû
“ö—Â$7u´¬çìWÁ–¼‘	¡¹Ý>kf?àï   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  % <?xml version="1.0"?><Features nextValidID="19"><Feature recentID="0" name="SDC1" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="1009-1941" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHQASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA*"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6180" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5389-6180" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6181-6249" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3093-3887" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4633-5218" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2255-2683" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2697-3026" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1985-2209" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2877-3012" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4061-4182" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6250-6354" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="987" consecutiveTranslationNumbering="1" maxRunOn="1941" maxFusedRunOn="1941" detectionMode="exactProteinMatch"><Segment range="922-987" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DYKDHDGDYKDHDIDYKDDDDK"/></Q></Feature><Feature recentID="13" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="4279-4285" color="#ffffff" type="standard"/><Segment range="4286-4303" color="#ffffff" type="standard"/><Segment name="-35" range="4304-4309" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4324-4345" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4231-4247" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4255-4271" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="913-922" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature></Features>
  	„<?xml version="1.0"?><Primers nextValidID="2"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="R2" sequence="gcgggtttaaacgggccctctagactcgagtcaggcatagaattcctcctgtttggtg" description="&lt;!DOCTYPE html PUBLIC &quot;-//W3C//DTD HTML 4.0//EN&quot; &quot;http://www.w3.org/TR/REC-html40/strict.dtd&quot;&gt;&lt;html&gt;&lt;body style=&quot; font-family:'SimSun'; font-size:9pt; font-weight:400; font-style:normal;&quot;&gt;&#10;&lt;p style=&quot;-qt-paragraph-type:empty; margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; -qt-block-indent:0; text-indent:0px; color:#000000;&quot;&gt;&lt;br&gt;&lt;/p&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="1913-1970" boundStrand="1" annealedBases="gcgggtttaaacgggccctctagactcgagtcaggcatagaattcctcctgtttggtg" meltingTemperature="74"><Component hybridizedRange="1913-1970" bases="gcgggtttaaacgggccctctagactcgagtcaggcatagaattcctcctgtttggtg"/></BindingSite><BindingSite simplified="1" location="1913-1970" boundStrand="1" annealedBases="gcgggtttaaacgggccctctagactcgagtcaggcatagaattcctcctgtttggtg" meltingTemperature="74"><Component hybridizedRange="1913-1970" bases="gcgggtttaaacgggccctctagactcgagtcaggcatagaattcctcctgtttggtg"/></BindingSite></Primer><Primer recentID="1" name="F2" sequence="gatgacaagcttggtaccgagctcggatccatgaggcgcgcggcgctctggctctggct" description="&lt;!DOCTYPE html PUBLIC &quot;-//W3C//DTD HTML 4.0//EN&quot; &quot;http://www.w3.org/TR/REC-html40/strict.dtd&quot;&gt;&lt;html&gt;&lt;body style=&quot; font-family:'SimSun'; font-size:9pt; font-weight:400; font-style:normal;&quot;&gt;&#10;&lt;p style=&quot;-qt-paragraph-type:empty; margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; -qt-block-indent:0; text-indent:0px; color:#000000;&quot;&gt;&lt;br&gt;&lt;/p&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="978-1036" boundStrand="0" annealedBases="gatgacaagcttggtaccgagctcggatccatgaggcgcgcggcgctctggctctggct" meltingTemperature="81"><Component hybridizedRange="978-1036" bases="gatgacaagcttggtaccgagctcggatccatgaggcgcgcggcgctctggctctggct"/></BindingSite><BindingSite simplified="1" location="978-1036" boundStrand="0" annealedBases="gatgacaagcttggtaccgagctcggatccatgaggcgcgcggcgctctggctctggct" meltingTemperature="81"><Component hybridizedRange="978-1036" bases="gatgacaagcttggtaccgagctcggatccatgaggcgcgcggcgctctggctctggct"/></BindingSite></Primer></Primers>
  Ÿ<Notes>
<UUID>c648e35c-d5f8-4682-a492-d695b71f42ca</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pECMV-3Ã—FLAG-SDC1</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="8:47:43">2018.8.31</Created>
<LastModified UTC="11:48:44">2025.8.26</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      HO  d               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
